A 35-year (1966-2000) bibliographic search using the Medline database showed the range of dose involved in adverse reactions was between 1mg and 36mg.
The adverse reactions were:
- One patient with autoimmune hepatitis
- One case of confusion due to overdose
- One case of optic neuropathy
- Four subjects with fragmented sleep
- One psychotic episode
- One case of nistagmus
- Four cases of seizures
- One case of headache
- Two cases of skin eruptions
